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The Isis Thesis is a transdisciplinary study of eight major ancient Egyptian texts, revealing that over 870 decoded signs, including art and architecture, communicate?modern scientific knowledge about microbiology and human potential for genetic immortality. Put simply, the Egyptian afterlife is the quantum domain, and their deities are signs for microbial genes and proteins, describing a biophysical process of horizontal gene transfer (DNA exchange between species)?for radical human evolution.The initial methodology included multiple reviews of the least corrupted Pyramid and Coffin Texts to categorize 108 key themes that were synthesized into 30 major idea strands, defining textual events and activities of major deities. From this analysis, a hypothetical biological model of primary signs emerged for further testing in six additional texts: Amduat, Book of Gates, Book of Two Ways, Edifice of Taharqa, Papyrus of Ani including the Theban Recension. Abductive reasoning allowed modifications to the working model with verification of Egyptian principles supported by modern scientific research. A logical, holist